Epstein-Barr virus (EBV) also called human herpesvirus 4, is best known as the cause of infectious mononucleosis (glandular fever), an acute but self-limiting disease affecting children and young adults. It occurs worldwide, and most people become infected with EBV at some point in their life. Symptoms of infectious mononucleosis are fever, sore throat, and swollen lymph glands. It is also associated with particular forms of cancer, such as Hodgkin’s lymphoma, Burkitt’s lymphoma, nasopharyngeal carcinoma, and central nervous system lymphomas associated with HIV.